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Prednisone to Prednisolone is impaired. Prednisone to Prednisolone is impaired. Corticosteroids by the body, and as such, the usual actions of corticosteroids become exaggerated and may be observed as side effects of this medicine. Prednisone may interact with estrogens and phenytoin. Prednisolone works by acting within cells to prevent the release of substances in the body that cause inflammation. Prednisone may interact with estrogens and phenytoin. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical.
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